Drug interactions
Tadalafil + Trandolapril
Severity: Moderate
Tadalafil and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil can add to the blood pressure lowering of ACE inhibitors such as trandolapril, causing dizziness or symptomatic hypotension in some patients.
What this interaction means in plain words
Tadalafil and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tadalafil belongs to Genitourinary; Trandolapril belongs to Cardiovascular.
Why it happens
Additive vasodilation through PDE5 inhibition and ACE inhibition.
What to do
Monitor blood pressure when starting tadalafil and advise on orthostatic precautions. Adjust antihypertensive therapy if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Tadalafil with Trandolapril?
MediHelp rates the interaction as moderate. Tadalafil and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil can add to the blood pressure lowering of ACE inhibitors such as trandolapril, causing dizziness or symptomatic hypotension in some patients.
How serious is the interaction between Tadalafil and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting tadalafil and advise on orthostatic precautions. Adjust antihypertensive therapy if hypotension occurs.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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