Drug interactions
Tadalafil + Triamterene
Severity: Minor
Tadalafil and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil may modestly add to the blood pressure lowering of triamterene, usually a mild effect. Symptomatic hypotension is possible with volume depletion or other antihypertensives.
What this interaction means in plain words
Tadalafil and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tadalafil belongs to Genitourinary; Triamterene belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from PDE5 inhibition and diuretic-related volume reduction.
What to do
Monitor blood pressure after starting tadalafil. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Tadalafil with Triamterene?
MediHelp rates the interaction as minor. Tadalafil and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil may modestly add to the blood pressure lowering of triamterene, usually a mild effect. Symptomatic hypotension is possible with volume depletion or other antihypertensives.
How serious is the interaction between Tadalafil and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting tadalafil. No dose change is usually needed.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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