Drug interactions
Tadalafil + Valsartan
Severity: Moderate
Tadalafil and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil can add to the blood pressure lowering of angiotensin receptor blockers like valsartan, with possible dizziness or symptomatic hypotension.
What this interaction means in plain words
Tadalafil and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tadalafil belongs to Genitourinary; Valsartan belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and angiotensin II receptor blockade.
What to do
Monitor blood pressure when tadalafil is started and counsel on orthostatic symptoms. Adjust doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Tadalafil with Valsartan?
MediHelp rates the interaction as moderate. Tadalafil and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil can add to the blood pressure lowering of angiotensin receptor blockers like valsartan, with possible dizziness or symptomatic hypotension.
How serious is the interaction between Tadalafil and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when tadalafil is started and counsel on orthostatic symptoms. Adjust doses if hypotension develops.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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