Drug interactions
Teicoplanin + Tobramycin
Severity: Major
Teicoplanin and Tobramycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney and the inner ear, so combined use increases the risk of nephrotoxicity and ototoxicity. Renal impairment further raises aminoglycoside levels.
What this interaction means in plain words
Teicoplanin and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Teicoplanin belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic and ototoxic effects.
What to do
Monitor creatinine and tobramycin trough levels regularly and assess hearing; reduce the dose or change therapy if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Teicoplanin
- Amphotericin b + Teicoplanin Major
- Cidofovir + Teicoplanin Major
- Neomycin + Teicoplanin Major
- Acyclovir + Teicoplanin Moderate
- Adefovir + Teicoplanin Moderate
- Amikacin + Teicoplanin Moderate
Frequently asked questions
Can I take Teicoplanin with Tobramycin?
MediHelp rates the interaction as major. Teicoplanin and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidney and the inner ear, so combined use increases the risk of nephrotoxicity and ototoxicity. Renal impairment further raises aminoglycoside levels.
How serious is the interaction between Teicoplanin and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine and tobramycin trough levels regularly and assess hearing; reduce the dose or change therapy if renal function declines.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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