Drug interactions
Neomycin + Teicoplanin
Severity: Major
Neomycin and Teicoplanin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can be nephrotoxic and ototoxic, and oral neomycin may be absorbed in patients with damaged gut mucosa or renal impairment. Combined use may increase the risk of kidney injury and hearing or vestibular damage.
What this interaction means in plain words
Neomycin and Teicoplanin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Neomycin belongs to Anti Bacterial; Teicoplanin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic and ototoxic effects.
What to do
Avoid the combination where an alternative exists; otherwise monitor renal function and teicoplanin levels, and assess hearing if therapy is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Teicoplanin
- Amphotericin b + Teicoplanin Major
- Cidofovir + Teicoplanin Major
- Teicoplanin + Tobramycin Major
- Acyclovir + Teicoplanin Moderate
- Adefovir + Teicoplanin Moderate
- Amikacin + Teicoplanin Moderate
Frequently asked questions
Can I take Neomycin with Teicoplanin?
MediHelp rates the interaction as major. Neomycin and Teicoplanin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can be nephrotoxic and ototoxic, and oral neomycin may be absorbed in patients with damaged gut mucosa or renal impairment. Combined use may increase the risk of kidney injury and hearing or vestibular damage.
How serious is the interaction between Neomycin and Teicoplanin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists; otherwise monitor renal function and teicoplanin levels, and assess hearing if therapy is prolonged.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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