Drug interactions
Telavancin + Vandetanib
Severity: Major
Telavancin and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib causes marked, concentration-dependent QT prolongation with a boxed warning for torsades de pointes and sudden death. Telavancin may add to this effect.
What this interaction means in plain words
Telavancin and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Telavancin belongs to Anti Bacterial; Vandetanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation, with vandetanib as the dominant contributor.
What to do
Avoid the combination and choose a non-QT-prolonging antibiotic. If it is unavoidable, perform more frequent ECG monitoring and keep potassium, magnesium and calcium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Telavancin with Vandetanib?
MediHelp rates the interaction as major. Telavancin and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib causes marked, concentration-dependent QT prolongation with a boxed warning for torsades de pointes and sudden death. Telavancin may add to this effect.
How serious is the interaction between Telavancin and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antibiotic. If it is unavoidable, perform more frequent ECG monitoring and keep potassium, magnesium and calcium normal.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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