Drug interactions
Telmisartan-amlodipine + Tolfenamic acid
Severity: Moderate
Telmisartan-amlodipine and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid, like other NSAIDs, can reduce the antihypertensive effect of telmisartan. The combination can also impair renal function and raise potassium, particularly in older or volume-depleted patients.
What this interaction means in plain words
Telmisartan-amlodipine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telmisartan-amlodipine belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing ARB action and increasing risk of renal impairment and hyperkalemia.
What to do
Monitor blood pressure, creatinine and potassium during combined use, and limit the NSAID to the lowest effective dose and shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Telmisartan-amlodipine and Tolfenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Telmisartan-amlodipine with Tolfenamic acid?
MediHelp rates the interaction as moderate. Telmisartan-amlodipine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolfenamic acid, like other NSAIDs, can reduce the antihypertensive effect of telmisartan. The combination can also impair renal function and raise potassium, particularly in older or volume-depleted patients.
How serious is the interaction between Telmisartan-amlodipine and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium during combined use, and limit the NSAID to the lowest effective dose and shortest duration.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
