Drug interactions
Telmisartan-amlodipine + Treprostinil
Severity: Moderate
Telmisartan-amlodipine and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and with telmisartan and amlodipine the blood pressure lowering effects are additive. Symptomatic hypotension may occur, particularly when starting or increasing doses.
What this interaction means in plain words
Telmisartan-amlodipine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telmisartan-amlodipine belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure reduction through prostacyclin receptor agonism plus AT1 blockade and calcium channel blockade.
What to do
Monitor blood pressure and symptoms of hypotension during treprostinil initiation and titration, and reduce the antihypertensive dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Telmisartan-amlodipine with Treprostinil?
MediHelp rates the interaction as moderate. Telmisartan-amlodipine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and with telmisartan and amlodipine the blood pressure lowering effects are additive. Symptomatic hypotension may occur, particularly when starting or increasing doses.
How serious is the interaction between Telmisartan-amlodipine and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension during treprostinil initiation and titration, and reduce the antihypertensive dose if needed.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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