Drug interactions
Telmisartan + Tolfenamic acid
Severity: Moderate
Telmisartan and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of telmisartan and reduce renal perfusion. The combination may cause acute kidney injury and hyperkalemia, especially in older, volume-depleted patients or those on diuretics.
What this interaction means in plain words
Telmisartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telmisartan belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins combined with ARB blockade of angiotensin II reduces glomerular filtration and potassium excretion.
What to do
Use the lowest effective NSAID dose for the shortest time, maintain hydration and monitor blood pressure, creatinine and potassium. Consider paracetamol or another alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Telmisartan with Tolfenamic acid?
MediHelp rates the interaction as moderate. Telmisartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of telmisartan and reduce renal perfusion. The combination may cause acute kidney injury and hyperkalemia, especially in older, volume-depleted patients or those on diuretics.
How serious is the interaction between Telmisartan and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, maintain hydration and monitor blood pressure, creatinine and potassium. Consider paracetamol or another alternative where possible.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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