Drug interactions
Telmisartan + Voclosporin
Severity: Major
Telmisartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause nephrotoxicity and hyperkalemia. Adding telmisartan can aggravate both through reduced glomerular filtration pressure and decreased aldosterone-driven potassium excretion.
What this interaction means in plain words
Telmisartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Telmisartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor afferent arteriolar vasoconstriction and reduced potassium secretion combine with angiotensin receptor blockade of efferent tone and aldosterone.
What to do
Monitor eGFR, serum creatinine and potassium frequently, particularly after dose changes. Reduce or stop voclosporin or telmisartan if renal function declines or hyperkalemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Telmisartan with Voclosporin?
MediHelp rates the interaction as major. Telmisartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can cause nephrotoxicity and hyperkalemia. Adding telmisartan can aggravate both through reduced glomerular filtration pressure and decreased aldosterone-driven potassium excretion.
How serious is the interaction between Telmisartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, serum creatinine and potassium frequently, particularly after dose changes. Reduce or stop voclosporin or telmisartan if renal function declines or hyperkalemia occurs.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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