Drug interactions
Tenecteplase + Tolmetin
Severity: Major
Tenecteplase and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin inhibits platelet function and can irritate the gastric mucosa, while tenecteplase is a thrombolytic that causes fibrinolysis. Together they raise the risk of serious bleeding, including gastrointestinal and intracranial hemorrhage.
What this interaction means in plain words
Tenecteplase and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tenecteplase belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive impairment of hemostasis: NSAID-induced platelet inhibition and mucosal injury plus plasminogen activation by tenecteplase.
What to do
Avoid starting the NSAID around thrombolysis unless clearly necessary. If combined, monitor closely for bleeding and hemoglobin changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Tenecteplase with Tolmetin?
MediHelp rates the interaction as major. Tenecteplase and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tolmetin inhibits platelet function and can irritate the gastric mucosa, while tenecteplase is a thrombolytic that causes fibrinolysis. Together they raise the risk of serious bleeding, including gastrointestinal and intracranial hemorrhage.
How serious is the interaction between Tenecteplase and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting the NSAID around thrombolysis unless clearly necessary. If combined, monitor closely for bleeding and hemoglobin changes.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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