Drug interactions
Teniposide + Tolbutamide
Severity: Moderate
Teniposide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolbutamide is highly protein bound and has been reported to displace teniposide from plasma proteins and reduce its clearance. This may increase free teniposide exposure and toxicity such as myelosuppression.
What this interaction means in plain words
Teniposide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Displacement of teniposide from plasma protein binding sites and possibly reduced clearance.
What to do
Monitor blood counts and teniposide toxicity if tolbutamide must be continued. Consider an alternative antidiabetic during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Teniposide with Tolbutamide?
MediHelp rates the interaction as moderate. Teniposide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolbutamide is highly protein bound and has been reported to displace teniposide from plasma proteins and reduce its clearance. This may increase free teniposide exposure and toxicity such as myelosuppression.
How serious is the interaction between Teniposide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and teniposide toxicity if tolbutamide must be continued. Consider an alternative antidiabetic during chemotherapy.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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