Drug interactions
Teniposide + Verapamil
Severity: Moderate
Teniposide and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and may increase teniposide exposure or intracellular retention, potentially enhancing myelosuppression and other toxicity. The clinical significance is not well defined.
What this interaction means in plain words
Teniposide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux of teniposide by verapamil.
What to do
Monitor blood counts and signs of teniposide toxicity, and reduce the teniposide dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Teniposide with Verapamil?
MediHelp rates the interaction as moderate. Teniposide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits P-glycoprotein and may increase teniposide exposure or intracellular retention, potentially enhancing myelosuppression and other toxicity. The clinical significance is not well defined.
How serious is the interaction between Teniposide and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of teniposide toxicity, and reduce the teniposide dose if toxicity develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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