Drug interactions
Tenofovir df + Valacyclovir
Severity: Moderate
Tenofovir df and Valacyclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acyclovir, the active metabolite of valacyclovir, and tenofovir both depend on renal elimination including tubular secretion. Concentrations of either can rise, and tenofovir nephrotoxicity may be increased.
What this interaction means in plain words
Tenofovir df and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion plus additive nephrotoxic potential.
What to do
Monitor serum creatinine and phosphate periodically. Adjust valacyclovir to renal function and reassess if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valacyclovir
- Talimogene laherparepvec + Valacyclovir Major
- Bacitracin + Valacyclovir Moderate
- Cilastatin-imipenem + Valacyclovir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir Moderate
- Imipenem / cilastatin / relebactam + Valacyclovir Moderate
- Imipenem / cilastatin + Valacyclovir Moderate
Frequently asked questions
Can I take Tenofovir df with Valacyclovir?
MediHelp rates the interaction as moderate. Tenofovir df and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acyclovir, the active metabolite of valacyclovir, and tenofovir both depend on renal elimination including tubular secretion. Concentrations of either can rise, and tenofovir nephrotoxicity may be increased.
How serious is the interaction between Tenofovir df and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and phosphate periodically. Adjust valacyclovir to renal function and reassess if renal function worsens.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Talimogene laherparepvec, Bacitracin, Cilastatin-imipenem. The full list is on the Valacyclovir page.
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