Drug interactions
Bacitracin + Valacyclovir
Severity: Moderate
Bacitracin and Valacyclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic bacitracin is nephrotoxic, and with valacyclovir, whose active form acyclovir is renally cleared, kidney injury risk increases. Topical bacitracin has negligible systemic exposure.
What this interaction means in plain words
Bacitracin and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bacitracin belongs to Miscellaneous; Valacyclovir belongs to Anti Virals.
Why it happens
Additive nephrotoxicity and reduced renal clearance of acyclovir.
What to do
Avoid systemic bacitracin with valacyclovir where possible. Otherwise maintain hydration, monitor creatinine and adjust valacyclovir dose for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valacyclovir
- Talimogene laherparepvec + Valacyclovir Major
- Cilastatin-imipenem + Valacyclovir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir Moderate
- Imipenem / cilastatin / relebactam + Valacyclovir Moderate
- Imipenem / cilastatin + Valacyclovir Moderate
- Mycophenolic acid + Valacyclovir Moderate
Other interactions of Bacitracin
- Bacitracin + Cidofovir Contraindicated
- Adefovir + Bacitracin Major
- Aldesleukin + Bacitracin Major
- Amikacin + Bacitracin Major
- Bacitracin + Carboplatin Major
- Bacitracin + Cisplatin Major
Frequently asked questions
Can I take Bacitracin with Valacyclovir?
MediHelp rates the interaction as moderate. Bacitracin and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic bacitracin is nephrotoxic, and with valacyclovir, whose active form acyclovir is renally cleared, kidney injury risk increases. Topical bacitracin has negligible systemic exposure.
How serious is the interaction between Bacitracin and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic bacitracin with valacyclovir where possible. Otherwise maintain hydration, monitor creatinine and adjust valacyclovir dose for renal function.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Talimogene laherparepvec, Cilastatin-imipenem, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Valacyclovir page.
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