Drug interactions
Tenofovir df + Vancomycin
Severity: Moderate
Tenofovir df and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the kidney, and tenofovir disoproxil is associated with proximal tubulopathy. Combined use raises the risk of acute kidney injury.
What this interaction means in plain words
Tenofovir df and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from vancomycin and tenofovir tubular injury.
What to do
Monitor serum creatinine and phosphate regularly while on both drugs. Guide vancomycin dosing by levels and consider tenofovir alafenamide or another alternative if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Tenofovir df with Vancomycin?
MediHelp rates the interaction as moderate. Tenofovir df and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can damage the kidney, and tenofovir disoproxil is associated with proximal tubulopathy. Combined use raises the risk of acute kidney injury.
How serious is the interaction between Tenofovir df and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and phosphate regularly while on both drugs. Guide vancomycin dosing by levels and consider tenofovir alafenamide or another alternative if renal function declines.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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