Drug interactions
Tenofovir disoproxil + Valacyclovir
Severity: Moderate
Tenofovir disoproxil and Valacyclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acyclovir, the active form of valacyclovir, and tenofovir are both renally eliminated, in part by tubular secretion. Competition for secretion may raise concentrations of either drug, and both can affect renal function at high exposures.
What this interaction means in plain words
Tenofovir disoproxil and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and potential additive nephrotoxicity.
What to do
Monitor serum creatinine and adjust doses to creatinine clearance. Maintain good hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tenofovir disoproxil and Valacyclovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Valacyclovir
- Talimogene laherparepvec + Valacyclovir Major
- Bacitracin + Valacyclovir Moderate
- Cilastatin-imipenem + Valacyclovir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir Moderate
- Imipenem / cilastatin / relebactam + Valacyclovir Moderate
- Imipenem / cilastatin + Valacyclovir Moderate
Frequently asked questions
Can I take Tenofovir disoproxil with Valacyclovir?
MediHelp rates the interaction as moderate. Tenofovir disoproxil and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acyclovir, the active form of valacyclovir, and tenofovir are both renally eliminated, in part by tubular secretion. Competition for secretion may raise concentrations of either drug, and both can affect renal function at high exposures.
How serious is the interaction between Tenofovir disoproxil and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and adjust doses to creatinine clearance. Maintain good hydration.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Talimogene laherparepvec, Bacitracin, Cilastatin-imipenem. The full list is on the Valacyclovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
