Drug interactions
Tenofovir disoproxil + Vancomycin
Severity: Moderate
Tenofovir disoproxil and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vancomycin can cause kidney injury, and tenofovir can cause proximal tubular toxicity. Using both increases the risk of acute kidney injury, especially with high vancomycin troughs or pre-existing renal disease.
What this interaction means in plain words
Tenofovir disoproxil and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity.
What to do
Monitor serum creatinine and vancomycin levels regularly. Switch to tenofovir alafenamide or another agent if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Tenofovir disoproxil with Vancomycin?
MediHelp rates the interaction as moderate. Tenofovir disoproxil and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vancomycin can cause kidney injury, and tenofovir can cause proximal tubular toxicity. Using both increases the risk of acute kidney injury, especially with high vancomycin troughs or pre-existing renal disease.
How serious is the interaction between Tenofovir disoproxil and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin levels regularly. Switch to tenofovir alafenamide or another agent if renal function deteriorates.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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