Drug interactions
Tenofovir disoproxil + Voclosporin
Severity: Moderate
Tenofovir disoproxil and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, is nephrotoxic, and tenofovir disoproxil can cause proximal tubular injury. Concurrent use may increase the risk of acute or chronic kidney injury.
What this interaction means in plain words
Tenofovir disoproxil and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity through calcineurin inhibitor-related afferent vasoconstriction and tenofovir tubular toxicity.
What to do
Monitor serum creatinine, eGFR, phosphate and electrolytes regularly. Reduce or stop either drug if renal function declines, per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Tenofovir disoproxil with Voclosporin?
MediHelp rates the interaction as moderate. Tenofovir disoproxil and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, is nephrotoxic, and tenofovir disoproxil can cause proximal tubular injury. Concurrent use may increase the risk of acute or chronic kidney injury.
How serious is the interaction between Tenofovir disoproxil and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, eGFR, phosphate and electrolytes regularly. Reduce or stop either drug if renal function declines, per labeling.
What other medicines interact with Voclosporin?
MediHelp also lists interactions of Voclosporin with, for example, Clarithromycin, Cyclosporin, Ensitrelvir. The full list is on the Voclosporin page.
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