Drug interactions
Teprotumumab + Vancomycin
Severity: Moderate
Teprotumumab and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teprotumumab can cause hearing impairment, including hearing loss and tinnitus, and vancomycin is also potentially ototoxic, especially at high levels or with renal impairment. Using them together may add to the risk of auditory damage.
What this interaction means in plain words
Teprotumumab and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teprotumumab belongs to Miscellaneous; Vancomycin belongs to Anti Bacterial.
Why it happens
Additive ototoxicity from independent mechanisms.
What to do
Perform baseline and periodic audiometry and ask patients about hearing changes. Monitor vancomycin trough or AUC and renal function, and stop or reassess therapy if hearing symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Teprotumumab with Vancomycin?
MediHelp rates the interaction as moderate. Teprotumumab and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teprotumumab can cause hearing impairment, including hearing loss and tinnitus, and vancomycin is also potentially ototoxic, especially at high levels or with renal impairment. Using them together may add to the risk of auditory damage.
How serious is the interaction between Teprotumumab and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform baseline and periodic audiometry and ask patients about hearing changes. Monitor vancomycin trough or AUC and renal function, and stop or reassess therapy if hearing symptoms appear.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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