Drug interactions
Terazosin + Trandolapril
Severity: Moderate
Terazosin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combining them can produce an exaggerated drop in pressure, especially after the first doses or a dose increase. Patients may experience dizziness, fainting or falls.
What this interaction means in plain words
Terazosin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Terazosin belongs to Genitourinary; Trandolapril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic blockade and ACE inhibition.
What to do
Start the added agent at a low dose, preferably at bedtime, and monitor blood pressure and orthostatic symptoms. Counsel the patient to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Terazosin with Trandolapril?
MediHelp rates the interaction as moderate. Terazosin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combining them can produce an exaggerated drop in pressure, especially after the first doses or a dose increase. Patients may experience dizziness, fainting or falls.
How serious is the interaction between Terazosin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the added agent at a low dose, preferably at bedtime, and monitor blood pressure and orthostatic symptoms. Counsel the patient to rise slowly.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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