Drug interactions
Terbinafine + Venlafaxine
Severity: Moderate
Terbinafine and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is converted to active desvenlafaxine by CYP2D6. Terbinafine can raise venlafaxine levels relative to its metabolite, which may increase blood pressure, serotonergic effects and nausea.
What this interaction means in plain words
Terbinafine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Terbinafine belongs to Anti Fungals; Venlafaxine belongs to Central Nervous System.
Why it happens
Terbinafine inhibits CYP2D6-mediated O-demethylation of venlafaxine.
What to do
Monitor blood pressure and for serotonergic adverse effects. Reduce the venlafaxine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Terbinafine with Venlafaxine?
MediHelp rates the interaction as moderate. Terbinafine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine is converted to active desvenlafaxine by CYP2D6. Terbinafine can raise venlafaxine levels relative to its metabolite, which may increase blood pressure, serotonergic effects and nausea.
How serious is the interaction between Terbinafine and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for serotonergic adverse effects. Reduce the venlafaxine dose if they occur.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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