Drug interactions
Testosterone buccal system + Tolazamide
Severity: Minor
Testosterone buccal system and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone may improve insulin sensitivity and lower blood glucose, which could increase the hypoglycemic effect of sulfonylureas. The effect is usually small.
What this interaction means in plain words
Testosterone buccal system and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Androgens improve insulin sensitivity and glucose utilization, adding to sulfonylurea action.
What to do
Monitor blood glucose when testosterone is started, and reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Testosterone buccal system with Tolazamide?
MediHelp rates the interaction as minor. Testosterone buccal system and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone may improve insulin sensitivity and lower blood glucose, which could increase the hypoglycemic effect of sulfonylureas. The effect is usually small.
How serious is the interaction between Testosterone buccal system and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when testosterone is started, and reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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