Drug interactions
Tezacaftor + Verapamil
Severity: Moderate
Tezacaftor and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase tezacaftor exposure, which can raise the risk of tezacaftor adverse effects. Tezacaftor is given with ivacaftor, whose exposure also increases.
What this interaction means in plain words
Tezacaftor and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Moderate CYP3A4 inhibition by verapamil reduces tezacaftor metabolism.
What to do
Adjust the tezacaftor/ivacaftor regimen to the labeled schedule for moderate CYP3A inhibitors. Monitor for adverse effects such as liver enzyme elevation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Tezacaftor with Verapamil?
MediHelp rates the interaction as moderate. Tezacaftor and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may increase tezacaftor exposure, which can raise the risk of tezacaftor adverse effects. Tezacaftor is given with ivacaftor, whose exposure also increases.
How serious is the interaction between Tezacaftor and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust the tezacaftor/ivacaftor regimen to the labeled schedule for moderate CYP3A inhibitors. Monitor for adverse effects such as liver enzyme elevation.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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