Drug interactions
Theophylline + Vonoprazan
Severity: Minor
Theophylline and Vonoprazan: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A inhibitor, but theophylline depends mainly on CYP1A2, so a meaningful rise in levels is unlikely.
What this interaction means in plain words
Theophylline and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Theophylline belongs to Respiratory; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by vonoprazan may slightly reduce a minor theophylline metabolic pathway.
What to do
No dose change is needed; check theophylline levels if signs of toxicity appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- VOQUEZNA DUAL PAK - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Theophylline with Vonoprazan?
MediHelp rates the interaction as minor. Theophylline and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vonoprazan is a weak CYP3A inhibitor, but theophylline depends mainly on CYP1A2, so a meaningful rise in levels is unlikely.
How serious is the interaction between Theophylline and Vonoprazan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; check theophylline levels if signs of toxicity appear.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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