Drug interactions
Thioridazine + Triazolam
Severity: Moderate
Thioridazine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a short-acting benzodiazepine hypnotic with a sedating phenothiazine increases drowsiness, psychomotor impairment and fall risk. Respiratory depression is possible at higher doses.
What this interaction means in plain words
Thioridazine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression via GABA-A potentiation and antihistamine and alpha-blocking effects.
What to do
Use the lowest effective doses and counsel on avoiding driving and alcohol. Monitor sedation, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Thioridazine with Triazolam?
MediHelp rates the interaction as moderate. Thioridazine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a short-acting benzodiazepine hypnotic with a sedating phenothiazine increases drowsiness, psychomotor impairment and fall risk. Respiratory depression is possible at higher doses.
How serious is the interaction between Thioridazine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel on avoiding driving and alcohol. Monitor sedation, particularly in older patients.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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