Drug interactions
Thioridazine + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Thioridazine and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization and heart rate, and thioridazine prolongs the QT interval. Systemic exposure from inhalation is low, but the combination may raise arrhythmia risk, especially with hypokalemia.
What this interaction means in plain words
Thioridazine and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and beta-agonist cardiac stimulation.
What to do
Prefer an alternative to thioridazine. If used together, monitor ECG and potassium and watch for palpitations or syncope.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Thioridazine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Thioridazine and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization and heart rate, and thioridazine prolongs the QT interval. Systemic exposure from inhalation is low, but the combination may raise arrhythmia risk, especially with hypokalemia.
How serious is the interaction between Thioridazine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to thioridazine. If used together, monitor ECG and potassium and watch for palpitations or syncope.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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