Drug interactions
Thioridazine + Yohimbine
Severity: Moderate
Thioridazine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises sympathetic tone and blood pressure and may cause tachycardia. Combined with thioridazine, which prolongs the QTc and has alpha-blocking effects, it may increase the risk of arrhythmia and produce unpredictable blood pressure changes. Evidence is limited.
What this interaction means in plain words
Thioridazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing adrenergic and pharmacodynamic effects together with thioridazine's QT prolongation; the mechanism is not firmly established.
What to do
Monitor blood pressure, heart rate and ECG, and avoid yohimbine in patients with QT risk factors. Consider stopping yohimbine if palpitations or hemodynamic changes appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Thioridazine with Yohimbine?
MediHelp rates the interaction as moderate. Thioridazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises sympathetic tone and blood pressure and may cause tachycardia. Combined with thioridazine, which prolongs the QTc and has alpha-blocking effects, it may increase the risk of arrhythmia and produce unpredictable blood pressure changes. Evidence is limited.
How serious is the interaction between Thioridazine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG, and avoid yohimbine in patients with QT risk factors. Consider stopping yohimbine if palpitations or hemodynamic changes appear.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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