Drug interactions
Thiotepa + Zidovudine
Severity: Moderate
Thiotepa and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, and thiotepa causes profound myelosuppression. Combined use may worsen neutropenia, anemia and thrombocytopenia.
What this interaction means in plain words
Thiotepa and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Thiotepa belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive myelosuppressive effects.
What to do
Monitor complete blood counts closely and consider an alternative to zidovudine during thiotepa treatment. Adjust or hold doses if severe cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Thiotepa
- Bendamustine + Thiotepa Major
- Chlorambucil + Thiotepa Major
- Clarithromycin + Thiotepa Major
- Cyclophosphamide + Thiotepa Major
- Dacarbazine + Thiotepa Major
- Deferiprone + Thiotepa Major
Frequently asked questions
Can I take Thiotepa with Zidovudine?
MediHelp rates the interaction as moderate. Thiotepa and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, and thiotepa causes profound myelosuppression. Combined use may worsen neutropenia, anemia and thrombocytopenia.
How serious is the interaction between Thiotepa and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and consider an alternative to zidovudine during thiotepa treatment. Adjust or hold doses if severe cytopenias occur.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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