Drug interactions
Thiothixene + Tranylcypromine
Severity: Moderate
Thiothixene and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an MAO inhibitor with an antipsychotic may add to sedation and orthostatic hypotension, and rarely contributes to serotonin toxicity or neuroleptic malignant syndrome. The risk is greatest at initiation or with dose increases.
What this interaction means in plain words
Thiothixene and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects: MAO inhibition raises monoamines while thiothixene blocks dopamine receptors, with additive sedative and hypotensive effects.
What to do
Monitor for mental status change, hyperthermia, rigidity and autonomic instability, and check blood pressure when starting or adjusting either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Thiothixene with Tranylcypromine?
MediHelp rates the interaction as moderate. Thiothixene and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an MAO inhibitor with an antipsychotic may add to sedation and orthostatic hypotension, and rarely contributes to serotonin toxicity or neuroleptic malignant syndrome. The risk is greatest at initiation or with dose increases.
How serious is the interaction between Thiothixene and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity and autonomic instability, and check blood pressure when starting or adjusting either drug.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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