Drug interactions
Thiothixene + Umeclidinium-vilanterol
Severity: Moderate
Thiothixene and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene, an antipsychotic, can prolong the QT interval and vilanterol may add to this and lower potassium. The combination may raise the risk of ventricular arrhythmias.
What this interaction means in plain words
Thiothixene and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-2 agonist-related hypokalemia.
What to do
Monitor ECG and electrolytes, particularly in patients with cardiac disease or other QT-prolonging drugs. Use an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Thiothixene with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Thiothixene and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene, an antipsychotic, can prolong the QT interval and vilanterol may add to this and lower potassium. The combination may raise the risk of ventricular arrhythmias.
How serious is the interaction between Thiothixene and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, particularly in patients with cardiac disease or other QT-prolonging drugs. Use an alternative if QTc becomes prolonged.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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