Drug interactions
Ticagrelor + Tofacitinib
Severity: Minor
Ticagrelor and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A4 inhibitor and may modestly raise tofacitinib exposure. A clinically important effect is unlikely at usual doses.
What this interaction means in plain words
Ticagrelor and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ticagrelor belongs to Cardiovascular; Tofacitinib belongs to Musculoskeletal.
Why it happens
Weak inhibition of CYP3A4 by ticagrelor slightly reduces tofacitinib metabolism.
What to do
No tofacitinib dose change is needed. Monitor for infection and cytopenias as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Ticagrelor with Tofacitinib?
MediHelp rates the interaction as minor. Ticagrelor and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticagrelor is a weak CYP3A4 inhibitor and may modestly raise tofacitinib exposure. A clinically important effect is unlikely at usual doses.
How serious is the interaction between Ticagrelor and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No tofacitinib dose change is needed. Monitor for infection and cytopenias as usual.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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