Drug interactions
Ticarcillin + Warfarin
Severity: Moderate
Ticarcillin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin can impair platelet function and may increase bleeding in patients taking warfarin, with occasional INR changes. The risk is greatest at high doses and in patients with renal impairment.
What this interaction means in plain words
Ticarcillin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
High-dose extended-spectrum penicillins cause platelet dysfunction, adding to warfarin's anticoagulant effect.
What to do
Monitor INR and for signs of bleeding during therapy, and adjust the warfarin dose as needed. Be particularly watchful in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Ticarcillin with Warfarin?
MediHelp rates the interaction as moderate. Ticarcillin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin can impair platelet function and may increase bleeding in patients taking warfarin, with occasional INR changes. The risk is greatest at high doses and in patients with renal impairment.
How serious is the interaction between Ticarcillin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and for signs of bleeding during therapy, and adjust the warfarin dose as needed. Be particularly watchful in renal impairment.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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