Drug interactions
Timolol + Tolmetin
Severity: Moderate
Timolol and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic NSAID use such as tolmetin can diminish the blood pressure lowering effect of beta-blockers like timolol, especially over longer courses. Control of hypertension may worsen.
What this interaction means in plain words
Timolol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Timolol belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis leads to sodium and fluid retention and reduced vasodilation.
What to do
Monitor blood pressure during prolonged co-therapy and increase antihypertensive therapy if required. Use the lowest NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Timolol with Tolmetin?
MediHelp rates the interaction as moderate. Timolol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic NSAID use such as tolmetin can diminish the blood pressure lowering effect of beta-blockers like timolol, especially over longer courses. Control of hypertension may worsen.
How serious is the interaction between Timolol and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prolonged co-therapy and increase antihypertensive therapy if required. Use the lowest NSAID dose for the shortest duration.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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