Drug interactions
Timolol + Triamterene
Severity: Moderate
Timolol and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed timolol, a nonselective beta-blocker, may slightly raise serum potassium. Together with triamterene the risk of hyperkalemia increases, mainly in renal impairment or diabetes.
What this interaction means in plain words
Timolol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Timolol belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene reduces renal potassium excretion while beta-2 blockade impairs cellular potassium uptake.
What to do
Monitor serum potassium and renal function during combined systemic use. Reduce or stop triamterene if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Timolol with Triamterene?
MediHelp rates the interaction as moderate. Timolol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed timolol, a nonselective beta-blocker, may slightly raise serum potassium. Together with triamterene the risk of hyperkalemia increases, mainly in renal impairment or diabetes.
How serious is the interaction between Timolol and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during combined systemic use. Reduce or stop triamterene if hyperkalemia develops.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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