Drug interactions
Tiotropium + Zotepine
Severity: Moderate
Tiotropium and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has appreciable anticholinergic activity and may add to the antimuscarinic effects of tiotropium, causing dry mouth, constipation, urinary retention and tachycardia. Zotepine also lowers the seizure threshold, though this is unrelated to tiotropium.
What this interaction means in plain words
Tiotropium and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects at muscarinic receptors.
What to do
Monitor for anticholinergic effects such as constipation and urinary retention, especially in older patients. Review the need for tiotropium if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Frequently asked questions
Can I take Tiotropium with Zotepine?
MediHelp rates the interaction as moderate. Tiotropium and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has appreciable anticholinergic activity and may add to the antimuscarinic effects of tiotropium, causing dry mouth, constipation, urinary retention and tachycardia. Zotepine also lowers the seizure threshold, though this is unrelated to tiotropium.
How serious is the interaction between Tiotropium and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as constipation and urinary retention, especially in older patients. Review the need for tiotropium if adverse effects appear.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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