Drug interactions
Tisagenlecleucel + Tocilizumab
Severity: Moderate
Tisagenlecleucel and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tocilizumab is the standard treatment for cytokine release syndrome after CAR-T infusion, so use together is expected. Prophylactic or prolonged use may reduce CAR-T expansion and adds to infection risk.
What this interaction means in plain words
Tisagenlecleucel and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tisagenlecleucel belongs to Oncology; Tocilizumab belongs to Musculoskeletal.
Why it happens
IL-6 receptor blockade adds immunosuppression and may dampen CAR-T cell activation and expansion.
What to do
Use tocilizumab for CRS per the labeled algorithm rather than prophylactically. Monitor for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Tisagenlecleucel with Tocilizumab?
MediHelp rates the interaction as moderate. Tisagenlecleucel and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tocilizumab is the standard treatment for cytokine release syndrome after CAR-T infusion, so use together is expected. Prophylactic or prolonged use may reduce CAR-T expansion and adds to infection risk.
How serious is the interaction between Tisagenlecleucel and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use tocilizumab for CRS per the labeled algorithm rather than prophylactically. Monitor for infection.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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