Drug interactions
Tisagenlecleucel + Trastuzumab
Severity: Moderate
Tisagenlecleucel and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tisagenlecleucel is a CD19 CAR T-cell therapy that causes prolonged cytopenias, hypogammaglobulinemia and infections. Trastuzumab may modestly add to infection risk. The combination is not well studied.
What this interaction means in plain words
Tisagenlecleucel and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tisagenlecleucel belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Possible additive immune and hematologic toxicity; mostly theoretical.
What to do
Avoid giving trastuzumab around CAR T infusion unless clearly needed. Monitor blood counts and for infection afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Tisagenlecleucel with Trastuzumab?
MediHelp rates the interaction as moderate. Tisagenlecleucel and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tisagenlecleucel is a CD19 CAR T-cell therapy that causes prolonged cytopenias, hypogammaglobulinemia and infections. Trastuzumab may modestly add to infection risk. The combination is not well studied.
How serious is the interaction between Tisagenlecleucel and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving trastuzumab around CAR T infusion unless clearly needed. Monitor blood counts and for infection afterwards.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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