Drug interactions
Tobramycin inhaled + Zidovudine
Severity: Minor
Tobramycin inhaled and Zidovudine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled tobramycin has low systemic absorption, so additive nephrotoxicity or ototoxicity with zidovudine is unlikely at usual doses. Zidovudine is not a notable nephrotoxin, so little interaction is expected.
What this interaction means in plain words
Tobramycin inhaled and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive toxicity; limited systemic exposure to inhaled tobramycin makes it improbable.
What to do
No change is required. Monitor renal function if the patient has renal impairment or other nephrotoxic exposures.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Tobramycin inhaled with Zidovudine?
MediHelp rates the interaction as minor. Tobramycin inhaled and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inhaled tobramycin has low systemic absorption, so additive nephrotoxicity or ototoxicity with zidovudine is unlikely at usual doses. Zidovudine is not a notable nephrotoxin, so little interaction is expected.
How serious is the interaction between Tobramycin inhaled and Zidovudine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is required. Monitor renal function if the patient has renal impairment or other nephrotoxic exposures.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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