Drug interactions
Tocilizumab + Ublituximab
Severity: Major
Tocilizumab and Ublituximab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function, so using them together may raise the risk of serious infections. Ublituximab depletes B cells for a prolonged period, which adds to the effect of tocilizumab.
What this interaction means in plain words
Tocilizumab and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tocilizumab belongs to Musculoskeletal; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from anti-CD20 B-cell depletion and interleukin-6 receptor blockade.
What to do
Avoid combining if an alternative exists. If used together, monitor closely for infection and review immunoglobulin levels and the timing of each drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Other interactions of Ublituximab
Frequently asked questions
Can I take Tocilizumab with Ublituximab?
MediHelp rates the interaction as major. Tocilizumab and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, so using them together may raise the risk of serious infections. Ublituximab depletes B cells for a prolonged period, which adds to the effect of tocilizumab.
How serious is the interaction between Tocilizumab and Ublituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if an alternative exists. If used together, monitor closely for infection and review immunoglobulin levels and the timing of each drug.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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