Drug interactions
Tofacitinib + Vinblastine
Severity: Major
Tofacitinib and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine causes myelosuppression, and tofacitinib suppresses immune function and may lower blood counts. Together they increase the risk of neutropenia and serious infections.
What this interaction means in plain words
Tofacitinib and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tofacitinib belongs to Musculoskeletal; Vinblastine belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Avoid the combination where possible. If both are used, monitor blood counts and watch for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Vinblastine
Frequently asked questions
Can I take Tofacitinib with Vinblastine?
MediHelp rates the interaction as major. Tofacitinib and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vinblastine causes myelosuppression, and tofacitinib suppresses immune function and may lower blood counts. Together they increase the risk of neutropenia and serious infections.
How serious is the interaction between Tofacitinib and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are used, monitor blood counts and watch for infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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