Drug interactions
Tolazamide + Triamcinolone acetonide injectable
Severity: Moderate
Tolazamide and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injected triamcinolone can raise blood glucose and counteract the effect of tolazamide. Hyperglycemia may last for days to a few weeks after a depot injection.
What this interaction means in plain words
Tolazamide and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing the action of the sulfonylurea.
What to do
Check blood glucose more often for one to two weeks after injection and temporarily increase antidiabetic therapy if needed. Reduce therapy again as the steroid effect wanes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Tolazamide with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Tolazamide and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injected triamcinolone can raise blood glucose and counteract the effect of tolazamide. Hyperglycemia may last for days to a few weeks after a depot injection.
How serious is the interaction between Tolazamide and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often for one to two weeks after injection and temporarily increase antidiabetic therapy if needed. Reduce therapy again as the steroid effect wanes.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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