Drug interactions
Tolazamide + Willow bark
Severity: Minor
Tolazamide and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylate, and large salicylate doses can lower blood glucose and potentiate sulfonylureas. At usual supplement doses the effect is likely small, but hypoglycemia is possible.
What this interaction means in plain words
Tolazamide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate has intrinsic hypoglycemic activity and may displace sulfonylureas from plasma protein binding.
What to do
Monitor blood glucose if willow bark is used regularly or at high doses with tolazamide. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Tolazamide with Willow bark?
MediHelp rates the interaction as minor. Tolazamide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylate, and large salicylate doses can lower blood glucose and potentiate sulfonylureas. At usual supplement doses the effect is likely small, but hypoglycemia is possible.
How serious is the interaction between Tolazamide and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if willow bark is used regularly or at high doses with tolazamide. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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