Drug interactions
Tolazamide + Xipamide
Severity: Moderate
Tolazamide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide, a thiazide-like diuretic, can raise blood glucose and reduce the effectiveness of tolazamide. Its potassium-lowering effect may also impair insulin secretion.
What this interaction means in plain words
Tolazamide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-like diuretics cause hypokalemia and reduced insulin release and sensitivity, antagonizing sulfonylurea action; increased renal clearance of tolazamide is not an established mechanism.
What to do
Monitor blood glucose and serum potassium after starting xipamide. Increase antidiabetic therapy as needed and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Tolazamide with Xipamide?
MediHelp rates the interaction as moderate. Tolazamide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide, a thiazide-like diuretic, can raise blood glucose and reduce the effectiveness of tolazamide. Its potassium-lowering effect may also impair insulin secretion.
How serious is the interaction between Tolazamide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting xipamide. Increase antidiabetic therapy as needed and correct hypokalemia.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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