Drug interactions
Tolbutamide + Tongkat ali
Severity: Minor
Tolbutamide and Tongkat ali: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tongkat ali has been reported in animal studies to lower blood glucose. Combined with tolbutamide, it may add to the hypoglycemic effect, though human data are scarce.
What this interaction means in plain words
Tolbutamide and Tongkat ali have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic activity; mechanism is not established.
What to do
Counsel patients about hypoglycemia symptoms and monitor glucose if the supplement is used. Adjust the tolbutamide dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Tongkat ali?
MediHelp rates the interaction as minor. Tolbutamide and Tongkat ali have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tongkat ali has been reported in animal studies to lower blood glucose. Combined with tolbutamide, it may add to the hypoglycemic effect, though human data are scarce.
How serious is the interaction between Tolbutamide and Tongkat ali?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about hypoglycemia symptoms and monitor glucose if the supplement is used. Adjust the tolbutamide dose as needed.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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