Drug interactions
Tolbutamide + Triamcinolone acetonide injectable
Severity: Moderate
Tolbutamide and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of injected triamcinolone can raise blood glucose and counteract tolbutamide. Hyperglycemia may last days to weeks after an injection.
What this interaction means in plain words
Tolbutamide and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and insulin resistance, opposing sulfonylurea action.
What to do
Monitor blood glucose for several days to weeks after injection and temporarily increase antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Tolbutamide and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic absorption of injected triamcinolone can raise blood glucose and counteract tolbutamide. Hyperglycemia may last days to weeks after an injection.
How serious is the interaction between Tolbutamide and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose for several days to weeks after injection and temporarily increase antidiabetic therapy if needed.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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