Drug interactions
Tolbutamide + Vanadium
Severity: Minor
Tolbutamide and Vanadium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vanadium compounds have insulin-mimetic activity and may lower blood glucose. With tolbutamide, they could increase the risk of hypoglycemia, though clinical evidence is limited.
What this interaction means in plain words
Tolbutamide and Vanadium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Insulin-mimetic effect of vanadium adds to sulfonylurea-induced insulin secretion.
What to do
Monitor blood glucose if vanadium supplements are used and lower the tolbutamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Vanadium?
MediHelp rates the interaction as minor. Tolbutamide and Vanadium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vanadium compounds have insulin-mimetic activity and may lower blood glucose. With tolbutamide, they could increase the risk of hypoglycemia, though clinical evidence is limited.
How serious is the interaction between Tolbutamide and Vanadium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if vanadium supplements are used and lower the tolbutamide dose if hypoglycemia occurs.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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