Drug interactions
Tolbutamide + Xipamide
Severity: Moderate
Tolbutamide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics such as xipamide can impair glucose tolerance and may reduce the effectiveness of sulfonylureas. Diuretic-induced hypokalemia may further impair insulin secretion.
What this interaction means in plain words
Tolbutamide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through diuretic-induced hypokalemia and reduced insulin release or sensitivity, rather than increased renal clearance of tolbutamide.
What to do
Monitor blood glucose and serum potassium, and adjust the tolbutamide dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Xipamide?
MediHelp rates the interaction as moderate. Tolbutamide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-like diuretics such as xipamide can impair glucose tolerance and may reduce the effectiveness of sulfonylureas. Diuretic-induced hypokalemia may further impair insulin secretion.
How serious is the interaction between Tolbutamide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium, and adjust the tolbutamide dose if control worsens.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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