Drug interactions
Tolmetin + Tolvaptan
Severity: Minor
Tolmetin and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan does not typically raise potassium meaningfully, so the combined potassium concern is weak. NSAIDs may affect renal function and fluid balance, but no established clinically important interaction exists.
What this interaction means in plain words
Tolmetin and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tolmetin belongs to Musculoskeletal; Tolvaptan belongs to Endocrine.
Why it happens
No well-established mechanism; NSAID-related renal effects may theoretically alter fluid and electrolyte balance.
What to do
No specific action is needed beyond routine monitoring of serum sodium, potassium and renal function in patients on tolvaptan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Tolmetin with Tolvaptan?
MediHelp rates the interaction as minor. Tolmetin and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan does not typically raise potassium meaningfully, so the combined potassium concern is weak. NSAIDs may affect renal function and fluid balance, but no established clinically important interaction exists.
How serious is the interaction between Tolmetin and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of serum sodium, potassium and renal function in patients on tolvaptan.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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