Drug interactions
Tolmetin + Trandolapril
Severity: Major
Tolmetin and Trandolapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin may blunt the blood pressure lowering effect of trandolapril. Together they can also reduce renal function, particularly in older, volume-depleted or renally impaired patients, and may raise potassium.
What this interaction means in plain words
Tolmetin and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tolmetin belongs to Musculoskeletal; Trandolapril belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins opposes ACE inhibitor effects and reduces glomerular perfusion.
What to do
Prefer a non-NSAID analgesic. If co-use is necessary, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Tolmetin with Trandolapril?
MediHelp rates the interaction as major. Tolmetin and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tolmetin may blunt the blood pressure lowering effect of trandolapril. Together they can also reduce renal function, particularly in older, volume-depleted or renally impaired patients, and may raise potassium.
How serious is the interaction between Tolmetin and Trandolapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic. If co-use is necessary, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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